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apalutamide will lessen the level or effect of ethinylestradiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with drugs which can be CYP3A4 substrates can result in lessen exposure to these medicines.Cigarette smoking tremendously will increase the op